ABOUT US

CEO MESSAGE

FREST was established to provide new medical values by utilizing its unique technology to edit gene structures at the mRNA level.

The history of medicine is also the history of technology. The development of synthesis technology has contributed greatly to the establishment of small molecule drugs, and the evolution of genetic engineering has contributed greatly to the leap forward in biologics.

Our "RNA editing technology" is the next generation technology after genome editing technology, and expected to open a new page of drug discovery by the development of drugs for diseases without an effective treatment, such as many genetic diseases.

The applications of RNA editing technology are wide-ranging. However, we cannot maximize the value of the technology on our own. We will make the most of our flexible mobility to collaborate with healthcare professionals, researchers, and pharmaceutical companies to expand the applications of RNA editing technology. We do our best to deliver medicines to patients suffering from diseases as quickly as possible.

CEO Nobuaki Takahashi, Ph.D. 


Our Team

Nobuaki Takahashi, Ph.D.

Chief Executive Officer



Takahashi joined FREST as CEO in August 2022 and leads all aspects of management and R&D. Previously, he worked in Kyowa Kirin where he held various important positions such as the head of RNA business group since 2019, and the head of antibody research group since 2012. He spent a few years working at Gemini Science, Kyowa Kirin's overseas R&D subsidiary since 1998. He also served as CTO of a biotech. He holds PhD in Science from Osaka University


Masatora Fukuda

Associate Professor Fukuoka University, Faculty of Science

Founder, Scientific Advisor


Fukuda has been engaged in RNA editing research over a decade and he is one of leading scientists in this field, with many collaborations with pharmaceutical companies. He founded FREST in 2020 based on his research outcomes. He joined Faculty of Science at Fukuoka University since 2010 after serving Kyoto University as a researcher and assistant professor. He holds a BS in Physics from Kwansei Gakuin University and a MS, PhD in Energy Science from Kyoto University.


Manabu Nakamura

Outside Director


He has extensive experience in private equity and venture capital investment. Prior to founding Shinsei Capital Partners in 2018, he served as Managing Director at Shinsei Corporate Investment starting in 2012, after working in the Pre-IPO investment team at Shinsei Bank since 2004. He began his career at The Long-Term Credit Bank of Japan in 1991 and was assigned to NED, a venture capital firm affiliated with the bank, in 1994. He was appointed as an Outside Director of FREST, Inc. in 2025. He holds a BA in Economics from Kyoto University and MBA from University of Rochester.


Hiroshi Yamamoto

Outside Director


He brings deep expertise in the pharmaceutical and biotech sectors throughout Asia. In 2019, he founded Eighty-Eighty Therapeutics and serves as its CEO. Since 2022, he has been Managing Director and Head of Asia at Locust Walk. He joined Eisai in 2004, overseeing marketing in Asia. He later worked at AbbVie, then joined Santen in 2014, where he was Vice President of Santen China. He was appointed as an Outside Director of FREST, Inc. in 2025. He holds a BA in Chemical Engineering from an MBA from NUS.


Toshiharu Ko

Auditor, CPA


He has built a robust career in finance and accounting, with a focus on auditing, advisory, and entrepreneurship. In 2016, he founded Flyheit LLC and became a representative partner, following the launch of his own CPA office in 2014. Earlier, he joined Deloitte in 1999 after becoming a certified public accountant, working in auditing, IPO support, and corporate rehabilitation. He began his career in 1995 at Long-Term Credit Bank. He was appointed as an auditor of FREST, Inc. in 2025. He holds a degree in Economics from Keio University.


Campany profile

Company:

FREST Inc.

Founded:

June 23, 2020

Capital:

90,000,000 JPY

Founder:

Masatora Fukuda (Associate Professor, Fukuoka Univ. Faculty of Science) 

CEO:

Nobuaki Takahashi

Shareholders:

Masatora Fukuda

Shinsei Capital Partners (New Life Science I Investment Limited Partnership)

Officers and employees

Head office & Laboratory:

2-26-1 Muraokahigashi, Fujisawa-shi, Kanagawa 251-8555

Shonan Health Innovation Park (iPark)

History

▶ Jun 2020

  Prof. Fukuda founded FREST

▶ Dec 2020

  Recognized as a Universty launched venture by Fukuoka University

▶ Feb 2021

        FREST entered into a license agreement and research collaboration with Fukuoka University

        FREST raised Seed funding round from Shinsei Capital Partners

▶ Aug 2022 

        Takahashi joined FREST as CEO FREST transferred its HQs to LINK-J

▶ Dec 2023

  FREST raised the second Seed funding round from Shinsei Capital Partners

▶ Dec 2023

  Laboratory opened in Shonan iPark

▶ Feb 2024

  Head office relocated to Shonan iPark

▶ May 2024

  FREST raised  funding from Shinsei Capital Partners by CB

▶ April 2025

  Takahashi introduced FREST's Technology at the Stargardt's connected in Japan 1st meeting

▶ April 2025

      The Board of Directors was established

        Nakamura and Yamamoto were appointed as Outside Directors, 

        Ko was appointed as Auditor